SLC52A2 — Solute carrier family 52 member 2
SLC52A2 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SLC52A2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | ERAD Proteasome Housekeeping | ADRM1, EIF6, EMC6, GLRX3, GNPTG, LRPAP1, MAP2K2, MED8 +16 more | View in SCUBA |
About the gene
| Synonyms | D15Ertd747e, FLJ11856, GPCR41, GPR172A, hRFT3, PAR1, RFVT2 |
|---|---|
| Chromosome | 8: 144333957-144361286 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Molecular function | Host cell receptor for virus entry, Receptor |
| Biological process | Transport |
Function
Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism. Humans are unable to synthesize vitamin B2/riboflavin and must obtain it via intestinal absorption. May also act as a receptor for 4- hydroxybutyrate (Probable). (Microbial infection) In case of infection by retroviruses, acts as a cell receptor to retroviral envelopes similar to the porcine endogenous retrovirus (PERV-A).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.