ERAD Proteasome
Gene co-expression module in Macrophages
| Category | Housekeeping |
|---|---|
| Genes | 25 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 25 genes have a known function matching the annotation |
Why this annotation
Hub genes SSR2 (signal sequence receptor/translocon-associated protein), EMC6 (ER membrane complex subunit 6), ADRM1 (proteasome 19S regulatory subunit/ubiquitin receptor), PSMD8 (proteasome 19S subunit), PSMB7 (proteasome 20S beta subunit), UFD1 (ubiquitin fusion degradation 1/ERAD), EIF6 (eIF6/ribosome biogenesis/60S maturation), LRPAP1 (LRP-associated protein/ER chaperone for LRP), TOR2A (torsin 2A/ER AAA-ATPase), MAP2K2 (MEK2/MAPK signaling), POLR2E (RNA pol II subunit), SCAND1 (SCAN domain/transcription), GLRX3 (glutaredoxin 3/redox). The module bridges ER quality control (SSR2, EMC6, LRPAP1, TOR2A, UFD1) and proteasome-mediated ERAD (ADRM1, PSMD8, PSMB7, UFD1). This is consistent with ER-associated degradation (ERAD). Neighbor M78 and M6 also contain proteasome subunits; M54 contains EMC3 — the neighborhood confirms an ER/UPS housekeeping cluster.
Genes
ADRM1, EIF6, EMC6, GLRX3, GNPTG, LRPAP1, MAP2K2, MED8, MIEN1, MYDGF, POLR2E, PPP1R14B, PSENEN, PSMB7, PSMD8, SCAND1, SLC52A2, SNF8, SSNA1, SSR2, TMEM208, TOR2A, TRAPPC4, UFD1, ZNF622
Most correlated modules
- Low-Coherence Mixed · correlation 0.97
- Proteasome UPS · correlation 0.94
- Proteasome UPS · correlation 0.94
- ER Protein Translocation · correlation 0.94
- Mixed Housekeeping · correlation 0.94
- Mitochondrial Housekeeping · correlation 0.94
- Glycolytic Redox Metabolism · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.