GLRX3 — Glutaredoxin 3
GLRX3 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GLRX3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | RNA & Redox Housekeeping RNA processing & translation | ANP32A, C11orf58, CCT6A, COPRS, DPM2, GGCT, LAGE3, NME1 +3 more | View in SCUBA |
| Endothelial | mRNA Splicing Stress RNA processing & translation | CCDC50, CCT6A, FAM114A1, PPM1G, RTRAF, SRSF9, TXNL4A, YWHAE | View in SCUBA |
| Innate lymphoid cells | Mitochondrial Metabolism Mitochondrial & OxPhos | ACTR10, ANP32A, APOL3, ATP6V1E1, ECHS1, ERCC1, ETFB, HIGD1A +12 more | View in SCUBA |
| Macrophages | ERAD Proteasome Housekeeping | ADRM1, EIF6, EMC6, GNPTG, LRPAP1, MAP2K2, MED8, MIEN1 +16 more | View in SCUBA |
About the gene
| Synonyms | bA500G10.4, GLRX4, GRX3, GRX4, PICOT, TXNL2 |
|---|---|
| Chromosome | 10: 130136391-130184521 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins. Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). Required for hemoglobin maturation. Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.