EIF6 — Eukaryotic translation initiation factor 6
EIF6 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
EIF6's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | ER protein processing Protein processing & ER | KDELR2, PDIA6, PSMC3, PSMC4, SDF2L1, SPCS2, UBE2L3 | View in SCUBA |
| Innate lymphoid cells | Mitochondrial Translation Mitochondrial & OxPhos | ABCF1, ARGLU1, ATG12, BAG1, C1orf35, CHCHD1, CHMP5, DNAJC7 +37 more | View in SCUBA |
| Macrophages | ERAD Proteasome Housekeeping | ADRM1, EMC6, GLRX3, GNPTG, LRPAP1, MAP2K2, MED8, MIEN1 +16 more | View in SCUBA |
About the gene
| Synonyms | b(2)gcn, EIF3A, ITGB4BP, p27BBP |
|---|---|
| Chromosome | 20: 35278907-35284985 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Initiation factor |
| Biological process | Protein biosynthesis, Ribosome biogenesis |
Function
Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis (By similarity). Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.