SLPI — Secretory leukocyte peptidase inhibitor
SLPI belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SLPI's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Goblet cells | Mucosal Antibacterial Defense Immune function | ANXA11, B3GNT7, C15orf48, C19orf33, CLIC1, CSTB, CYSTM1, ELOB +8 more | View in SCUBA |
About the gene
| Synonyms | ALK1, ALP, BLPI, HUSI, HUSI-I, WAP4, WFDC4 |
|---|---|
| Chromosome | 20: 45252239-45254564 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Plasma proteins, Predicted secreted proteins |
| Molecular function | Antibiotic, Antimicrobial, Protease inhibitor, Serine protease inhibitor |
| Biological process | Immunity, Innate immunity |
Function
Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. Modulates the inflammatory and immune responses after bacterial infection, and after infection by the intracellular parasite L.major. Down-regulates responses to bacterial lipopolysaccharide (LPS) (By similarity). Plays a role in regulating the activation of NF-kappa- B and inflammatory responses. Has antimicrobial activity against mycobacteria, but not against salmonella. Contributes to normal resistance against infection by M.tuberculosis. Required for normal resistance to infection by L.major. Required for normal wound healing, probably by preventing tissue damage by limiting protease activity (By similarity). Together with ELANE, required for normal differentiation and proliferation of bone marrow myeloid cells.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.