CREB3L2 — CAMP responsive element binding protein 3 like 2
CREB3L2 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CREB3L2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Inflammatory effector Immune regulation | C3AR1, CAST, CLDND1, CMTM3, EIF4E3, EPB41, FYCO1, IL18R1 +9 more | View in SCUBA |
| Endothelial | Vascular Barrier Integrity migration & adhesion | APCDD1, DYSF, GJA1, GRAMD1A, HDAC1, IGF2R, LAMB1, LGMN +11 more | View in SCUBA |
| Enterocytes | Endocytic nutrient uptake Absorption | CDA, DAB2, DNAH7, EGLN3, LRP1, SLC43A2, SLC6A8 | View in SCUBA |
| Macrophages | TGF-beta Signaling Inflammatory | APPL1, BBX, C6orf89, CCDC50, HCLS1, NCKAP1L, NFIC, POGK +9 more | View in SCUBA |
About the gene
| Synonyms | BBF2H7, TCAG_1951439 |
|---|---|
| Chromosome | 7: 137874979-138002086 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Transcription factors |
| Molecular function | Activator, Developmental protein, DNA-binding |
| Biological process | Transcription, Transcription regulation, Unfolded protein response |
Function
Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes (By similarity). In a neuroblastoma cell line, protects cells from ER stress-induced death. In vitro activates transcription of target genes via direct binding to the CRE site.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.