Mucosal Antibacterial Defense
Gene co-expression module in Goblet cells
| Category | Immune function |
|---|---|
| Genes | 17 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 12 of 17 genes have a known function matching the annotation |
Why this annotation
The module is dominated by secreted antimicrobial and protease-inhibitor proteins characteristic of mucosal defense: SLPI (secretory leukocyte protease inhibitor), PI3 (elafin, elastase inhibitor with direct antimicrobial activity), and CSTB (cystatin B, cysteine protease inhibitor). Supporting genes include LGALS3 (galectin-3, pathogen-binding lectin), S100A10 (epithelial barrier/annexin signaling), SFN (14-3-3σ, epithelial integrity), CYSTM1, C19orf33, and MUC12. Upregulation in remission states is consistent with restoration of homeostatic mucosal antimicrobial programs in goblet cells rather than active inflammatory responses.
Genes
ANXA11, B3GNT7, C15orf48, C19orf33, CLIC1, CSTB, CYSTM1, ELOB, LGALS3, MISP, MUC12, PI3, S100A10, SAT1, SFN, SLPI, TMC5
Most correlated modules
- S100 Calcium Signaling · correlation 0.77
- Basement Membrane Remodeling · correlation 0.67
- Epithelial Differentiation Metabolism · correlation 0.62
- Inflammatory goblet response · correlation 0.61
- Mucosal Innate Defense · correlation 0.53
- EGF-Driven Wound Repair · correlation 0.53
- DUOX2 Epithelial Inflammation · correlation 0.51
- Stress Survival Response · correlation 0.44
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.