Secretory Differentiation
Gene co-expression module in Colonocytes
| Category | Secretion |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 14 of 21 genes have a known function matching the annotation |
Why this annotation
Hub genes CREB3L1 and CREB3L2 are ER stress-responsive transcription factors that drive secretory cell differentiation (goblet/enteroendocrine programs). SEC24D (COPII vesicle coat), QSOX1 (oxidative protein folding in secretory pathway), SLPI (secreted protease inhibitor), GALNT5 (mucin-type O-glycosylation), SGMS1 (sphingomyelin synthase/Golgi), ATP2C1 (Golgi Ca2+ ATPase/SPCA1), S100P (calcium-binding, inflammation), MLPH (vesicle transport/exocytosis), and PGM3 (UDP-GlcNAc synthesis for glycosylation) together define a secretory differentiation program with Golgi/vesicle trafficking. Strong inf_colono enrichment. Neighbor to M26 (UPR) and M15 (ER folding), consistent with a secretory cell differentiation program.
Genes
Most correlated modules
- Unfolded Protein Response · correlation 0.87
- ER Glycoprotein Folding · correlation 0.83
- Inflammasome Activation · correlation 0.81
- Chromatin Regulatory Response · correlation 0.78
- Inflammatory Stress Response · correlation 0.78
- Actin Cytoskeletal Regulation · correlation 0.77
- Inflammatory Regenerative State · correlation 0.77
- Focal Adhesion Migration · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.