SPSB1 — SplA/ryanodine receptor domain and SOCS box containing 1
SPSB1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SPSB1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Endothelial Cell Migration migration & adhesion | CISD1, CTHRC1, GALNT1, MARCKS, MARCKSL1, NARF, PHLDB2, RHOJ +5 more | View in SCUBA |
| Fibroblasts | AP-1 Inflammatory Stress Inflammatory | ALAS1, ATP13A3, BATF3, CCDC71L, DDX21, FOSL1, NINJ1, PANX1 +1 more | View in SCUBA |
About the gene
| Synonyms | SSB-1 |
|---|---|
| Chromosome | 1: 9292894-9369532 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Ubl conjugation pathway |
Function
Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2. Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.