TDRD9 — Tudor domain containing 9
TDRD9 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TDRD9's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Monocytes | Classical Monocyte Trafficking Migration & adhesion | ANXA6, CKAP4, EMB, F5, GCA, MAP2K6, MPP7, MSRB1 +4 more | View in SCUBA |
About the gene
| Synonyms | C14orf75, DKFZp434N0820, FLJ36164, NET54 |
|---|---|
| Chromosome | 14: 103928456-104052667 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Developmental protein, Helicase, Hydrolase |
| Biological process | Differentiation, Meiosis, RNA-mediated gene silencing, Spermatogenesis |
Function
ATP-binding RNA helicase required during spermatogenesis. Required to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Acts downstream of piRNA biogenesis: exclusively required for transposon silencing in the nucleus, suggesting that it acts as a nuclear effector in the nucleus together with PIWIL4.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.