TG — Thyroglobulin
TG belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TG's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Neutrophils | PI3K Chemotaxis Signaling Chemotaxis | ABCA1, ACSL1, ALDH1A2, CRK, INPP5A, LIMK2, NUP98, PIK3R5 +6 more |
About the gene
| Synonyms | AITD3, TGN |
|---|---|
| Chromosome | 8: 132866958-133134903 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Hormone, Thyroid hormone |
| Biological process | Thyroid hormones biosynthesis |
Function
Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling in the thyroid follicle lumen. Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream. One dimer produces 7 thyroid hormone molecules
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.