CRK — CRK proto-oncogene, adaptor protein
CRK belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CRK's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Inflammatory Stress Response Stress | DLC1, GCLM, IFT20, KRAS, ODC1, SBDS, SERP1, SERPINH1 +7 more | View in SCUBA |
| Neutrophils | PI3K Chemotaxis Signaling Chemotaxis | ABCA1, ACSL1, ALDH1A2, INPP5A, LIMK2, NUP98, PIK3R5, PTPN12 +6 more | |
| Pericytes | BMP Receptor Signaling Developmental | BMPR2, LRRC8C, PLEKHG1, PTPRN2, RBMS2, RPS6KA2, SNAP23, TMEM181 +1 more | View in SCUBA |
About the gene
| Chromosome | 17: 1420689-1463162 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Involved in cell branching and adhesion mediated by BCAR1- CRK-RAPGEF1 signaling and activation of RAP1. Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.