NUP98 — Nucleoporin 98 and 96 precursor
NUP98 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NUP98's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | TCR early activation TCR/AP1/NFKb pathway | ARIH1, BRAF, CCNT1, CLEC2D, ELL2, EMD, FAM133B, FOSL2 +11 more | View in SCUBA |
| Gamma-delta T cells | Chromatin Epigenetic Regulation DNA/chromatin regulation | ADNP2, ARID4B, CEBPZ, ELL2, ENSG00000285976, ETF1, HIPK1, JMJD1C +17 more | |
| Macrophages | Endosomal Vesicle Trafficking Vesicular traficking | ADAM17, AP3B1, ARFGEF1, ARID1B, ARK2N, ASAP1, ATF6, ATP11A +48 more | View in SCUBA |
| Mucosal-associated invariant T cell | Nuclear-Cytoplasmic Transport Housekeeping | AP1G1, CNOT1, INO80D, JARID2, NAA50, PLEKHA2, PLEKHM1, RANBP2 +3 more | |
| Neutrophils | PI3K Chemotaxis Signaling Chemotaxis | ABCA1, ACSL1, ALDH1A2, CRK, INPP5A, LIMK2, PIK3R5, PTPN12 +6 more |
About the gene
| Synonyms | NUP196, NUP96, Nup98-96, Nup98-Nup96 |
|---|---|
| Chromosome | 11: 3671083-3797792 |
| Predicted location | Intracellular, Membrane |
| Essential gene | Yes |
| Protein class | Cancer-related genes, Disease related genes, Essential proteins, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Molecular function | Hydrolase, Protease, Serine protease |
| Biological process | Host-virus interaction, mRNA transport, Protein transport, Translocation, Transport |
Function
Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC. May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes. Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body). (Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.