PI3K Chemotaxis Signaling
Gene co-expression module in Neutrophils
| Category | Chemotaxis |
|---|---|
| Genes | 15 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 15 genes have a known function matching the annotation |
Why this annotation
PIK3R5 encodes the p101 regulatory subunit of PI3Kγ, a master regulator of neutrophil chemotaxis downstream of GPCRs. LIMK2 regulates actin dynamics during migration. CRK and SIPA1L1 are cytoskeletal adaptor/GTPase regulators. INPP5A modulates inositol phosphate signaling. TAB2 links to TAK1 in chemokine receptor signaling. ABCA1 and ACSL1 suggest concurrent lipid metabolism. ALDH1A2 (retinoic acid synthesis) may reflect differentiation context. The PI3Kγ-LIMK axis strongly points to neutrophil chemotaxis/migration programming.
Genes
ABCA1, ACSL1, ALDH1A2, CRK, INPP5A, LIMK2, NUP98, PIK3R5, PTPN12, SIPA1L1, SUSD6, TAB2, TG, UBAP1, ZSWIM6
Most correlated modules
- Ubiquitin Regulatory Signaling · correlation 0.96
- TLR2 Innate Signaling · correlation 0.95
- Neutrophil Survival FOXO-MK2 · correlation 0.94
- Endocytic Vesicle Trafficking · correlation 0.94
- Endosomal Vesicle Trafficking · correlation 0.93
- Granulopoiesis Transcriptional · correlation 0.91
- Cytoskeletal Remodeling · correlation 0.89
- NF-κB Inflammatory Transcription · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.