TUBG1 — Tubulin gamma 1
TUBG1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TUBG1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | S-phase Progression Cell cycle | CENPH, CENPM, CENPU, DNAJC9, DSCC1, EBP, NCAPH2, PCLAF +5 more | View in SCUBA |
About the gene
| Synonyms | TUBG, TUBGCP1 |
|---|---|
| Chromosome | 17: 42609641-42615238 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Essential proteins, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
Function
Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.