PCLAF — PCNA clamp associated factor

PCLAF belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

PCLAF's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Cell Cycle G1/S Cell cycle	CARHSP1, CBX5, CENPM, DNMT1, GMNN, HMGB2, HMGN2, MND1 +8 more	View in SCUBA
CD8⁺ T cells	S-phase Progression Cell cycle	CENPH, CENPM, CENPU, DNAJC9, DSCC1, EBP, NCAPH2, RRM1 +5 more	View in SCUBA
Endothelial	S-phase Proliferation Cell cycle	ATAD2, ATAD5, BRCA1, BRCA2, CENPH, CENPK, CENPU, DHFR +11 more	View in SCUBA
Gamma-delta T cells	S-phase Replication Cell cycle	ATAD2, ATAD5, BRCA2, CDT1, CENPH, CENPM, CENPU, CLSPN +13 more
Goblet cells	S-phase DNA Replication Cell cycle	ASF1B, BRCA1, CDC6, CENPU, DHFR, FEN1, MYBL2, TK1 +1 more	View in SCUBA
Hematopoietic progenitor cells	DNA Replication S-phase Cell cycle	CDT1, CENPH, CENPK, CHEK1, E2F1, FEN1, GINS2, GMNN +4 more
Macrophages	S-phase DNA Replication Cell cycle	ATAD2, ATAD5, BARD1, BRCA1, CENPK, CENPM, CENPU, CLSPN +31 more	View in SCUBA
Monocytes	Mitotic Cell Cycle Cell cycle	BIRC5, CENPF, H1-5, H2AC14, MKI67, PTTG1, STMN1, TROAP	View in SCUBA
Natural Killer cells	S-phase Replication Cell cycle	CDT1, CENPM, CENPU, CLSPN, FANCI, RRM2, TYMS	View in SCUBA

About the gene

Synonyms	KIAA0101, NS5ATP9, OEATC-1, p15(PAF), PAF15
Chromosome	15: 64364304-64387687
Predicted location	Intracellular
Essential gene	No
Protein class	Predicted intracellular proteins
Biological process	DNA damage, DNA repair

Function

PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork- blocking lesions. Also acts as a regulator of centrosome number

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.