S-phase Progression
Gene co-expression module in CD8⁺ T cells
| Category | Cell cycle |
|---|---|
| Genes | 14 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 11 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes TYMS (thymidylate synthase, DNA synthesis), CENPM, CENPU, CENPH (centromere proteins), PCLAF (PCNA-associated), DSCC1 (DNA replication), RRM1 (ribonucleotide reductase), NCAPH2 (condensin II), TUBG1 (gamma-tubulin, mitotic spindle), TCF19 (S-phase TF) collectively define S-phase entry and mitotic preparation. TMEM106C and DNAJC9 are co-regulated in proliferating cells. EBP is a cholesterol biosynthesis enzyme induced in cycling cells. This is a tightly coherent S/G2-phase cell cycle module. Neighbor context: all batch modules share the cell cycle theme, with M86 focused on DNA synthesis enzymes and centromere assembly components.
Genes
CENPH, CENPM, CENPU, DNAJC9, DSCC1, EBP, NCAPH2, PCLAF, RRM1, SIVA1, TCF19, TMEM106C, TUBG1, TYMS
Most correlated modules
- Replication Licensing · correlation 0.98
- DNA Replication Fork · correlation 0.96
- Cellular Housekeeping · correlation 0.95
- G2/M Checkpoint · correlation 0.95
- Replication Stress Checkpoint · correlation 0.94
- Histone Synthesis S-phase · correlation 0.93
- Mitotic Spindle · correlation 0.93
- Mitochondrial Metabolism · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.