EBP — EBP cholestenol delta-isomerase
EBP belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
EBP's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | S-phase Progression Cell cycle | CENPH, CENPM, CENPU, DNAJC9, DSCC1, NCAPH2, PCLAF, RRM1 +5 more | View in SCUBA |
| Endothelial | Lysosomal Autophagy Program Stress | ABCD4, AKR1A1, ASPH, CD63, CFI, GNS, MAP1LC3A, MDH1 +4 more | View in SCUBA |
| Gamma-delta T cells | Transcriptional Repressor Complex DNA/chromatin regulation | BAG1, CAB39, CLEC2B, FBXO31, GFI1, MAN1A1, MAP2K1, MFSD6 +14 more | |
| Goblet cells | Sterol Biosynthesis Housekeeping | ACAT2, CKLF, COPS9, DHCR24, FDPS, PLP2, TXNDC17 | View in SCUBA |
About the gene
| Synonyms | CDPX2, CHO2, CPX, CPXD |
|---|---|
| Chromosome | X: 48521799-48528716 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins |
| Molecular function | Hydrolase, Isomerase |
| Biological process | Cholesterol biosynthesis, Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism |
Function
Isomerase that catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers a catalytic step in the postlanosterol biosynthesis of cholesterol. Component of the microsomal antiestrogen binding site (AEBS), a multiproteic complex at the ER membrane that consists of an association between EBP and 7-dehydrocholesterol reductase/DHCR7. This complex is responsible for cholesterol-5,6-epoxide hydrolase (ChEH) activity, which consists in the hydration of cholesterol-5,6-epoxides (5,6-EC) into cholestane- 3beta,5alpha,6beta-triol (CT). The precise role of each component of this complex has not been described yet.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.