CENPH — Centromere protein H
CENPH belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CENPH's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | DNA Replication Cell cycle | CDC45, DHFR, FEN1, GINS2, MCM3, MCM5, MCM7, PCNA +3 more | View in SCUBA |
| CD8⁺ T cells | S-phase Progression Cell cycle | CENPM, CENPU, DNAJC9, DSCC1, EBP, NCAPH2, PCLAF, RRM1 +5 more | View in SCUBA |
| Endothelial | S-phase Proliferation Cell cycle | ATAD2, ATAD5, BRCA1, BRCA2, CENPK, CENPU, DHFR, EZH2 +11 more | View in SCUBA |
| Gamma-delta T cells | S-phase Replication Cell cycle | ATAD2, ATAD5, BRCA2, CDT1, CENPM, CENPU, CLSPN, DHFR +13 more | |
| Hematopoietic progenitor cells | DNA Replication S-phase Cell cycle | CDT1, CENPK, CHEK1, E2F1, FEN1, GINS2, GMNN, PCLAF +4 more |
About the gene
| Chromosome | 5: 69189574-69210357 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
Function
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.