UBE2D1 — Ubiquitin conjugating enzyme E2 D1
UBE2D1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
UBE2D1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Innate lymphoid cells | ILC Survival Residency Gut residency | ARID4B, BAZ1A, BCL2A1, CD44, CSF2, CTSH, CXCL8, DUSP4 +25 more | View in SCUBA |
About the gene
| Synonyms | E2(17)KB1, SFT, UBC4/5, UBCH5, UbcH5A |
|---|---|
| Chromosome | 10: 58334979-58370751 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Transferase |
| Biological process | Ubl conjugation pathway |
Function
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyubiquitination of CYP3A4.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.