ILC Survival Residency
Gene co-expression module in Innate lymphoid cells
| Category | Gut residency |
|---|---|
| Genes | 34 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 20 genes have a known function matching the annotation |
Why this annotation
Moderate coherence module with strong core members BCL2A1, LGALS3, PHLDA1, SDC4, PIM3, TANK, ARID4B. The dominant program is NF-κB-driven survival and tissue residency: BCL2A1 (anti-apoptotic), PIM3 (pro-survival kinase), TRAF4/TANK (NF-κB activators), LGALS3 (galectin-3, tissue residency), LAYN (layilin, tissue residency), SDC4 (syndecan-4, adhesion), ENTPD1 (CD39, tissue-resident immune regulation), RBPJ (Notch signaling, ILC3 residency), TNFRSF18 (GITR, immune regulation). Enrichment in res_ILC3 and ILC1 subsets fits gut-resident ILC survival programs. CSF2 adds an inflammatory/activation component. Neighbor M2 represents a more cytotoxic ILC1 effector program; M65 represents the complementary survival/residency arm of ILC activation in the gut.
Genes
ARID4B, BAZ1A, BCL2A1, CD44, CSF2, CTSH, CXCL8, DUSP4, ENTPD1, HSP90B1, LAYN, LGALS3, MAST4, NFKBID, NINJ1, PHACTR2, PHLDA1, PIM3, POLR2K, POP5, PPA1, PPFIBP1, RAB9A, RABGGTB, RBPJ, SDC4, SMS, TANK, TNFRSF18, TNFRSF4, TRAF4, UBE2D1, USP14, ZNF706
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.