BAZ1A — Bromodomain adjacent to zinc finger domain 1A
BAZ1A belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BAZ1A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Wnt Angiogenic Remodeling ECM remodeling | ADAMTS4, ADGRL2, FKBP11, IL4R, LDLRAD3, LEF1, MTHFD2, NEURL1B +5 more | View in SCUBA |
| Gamma-delta T cells | Osmotic Stress Response Stress | BMPR2, HIPK3, HTT, LIX1L, MAPRE2, NFAT5, RALGAPB, RTN4 +6 more | |
| Innate lymphoid cells | ILC Survival Residency Gut residency | ARID4B, BCL2A1, CD44, CSF2, CTSH, CXCL8, DUSP4, ENTPD1 +25 more | View in SCUBA |
| Lymphatic endothelial | DNA Damage Apoptosis DNA/chromatin regulation | AZIN1, HNRNPC, IVNS1ABP, MAPK6, OTUD4, PHLDB2, SPEN, STX3 +4 more | View in SCUBA |
| Macrophages | RNA Processing Housekeeping Housekeeping | BDP1, CCAR1, CCDC88A, CLIP1, CUL5, DHX36, DNM1L, EP400 +32 more | View in SCUBA |
| Monocytes | IRF1 Innate Activation Innate immunity | CFLAR, FNIP2, IRF1, MARCKS, NABP1, THAP2, TRIM69, ZFYVE16 | View in SCUBA |
About the gene
| Synonyms | ACF1, hACF1, WALp1, WCRF180 |
|---|---|
| Chromosome | 14: 34752731-34875647 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Transcription, Transcription regulation |
Function
Regulatory subunit of the ATP-dependent ACF-1 and ACF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and slide edge- and center-positioned histone octamers away from their original location on the DNA template to facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair. Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner. The ACF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the ACF-5 ISWI chromatin remodeling complex. Has a role in sensing the length of DNA which flank nucleosomes, which modulates the nucleosome spacing activity of the ACF-5 ISWI chromatin remodeling complex. Involved in DNA replication and together with SMARCA5/SNF2H is required for replication of pericentric heterochromatin in S-phase. May have a role in nuclear receptor-mediated transcription repression.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.