ZDHHC18 — Zinc finger DHHC-type palmitoyltransferase 18
ZDHHC18 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ZDHHC18's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Polycomb Transcriptional Control DNA/chromatin regulation | AMFR, ATMIN, BRD7, CBX4, CCNY, CD81, CDK2AP1, CSNK1E +17 more | |
| Mucosal-associated invariant T cell | Transcriptional Co-regulation DNA/chromatin regulation | ALYREF, CCNT1, CSNK1E, FBXO7, MXRA7, PLEKHM2, PLXND1, TADA2B +1 more |
About the gene
| Synonyms | DKFZp667O2416 |
|---|---|
| Chromosome | 1: 26826688-26857604 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted membrane proteins |
| Molecular function | Acyltransferase, Transferase |
| Biological process | Immunity, Innate immunity |
Function
Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates, such as CGAS, HRAS and LCK. Acts as a negative regulator of the cGAS-STING pathway be mediating palmitoylation and inactivation of CGAS. May also have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and therefore regulate G protein-coupled receptor signaling.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.