Transcriptional Co-regulation
Gene co-expression module in Mucosal-associated invariant T cell
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 10 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes include CCNT1 (Cyclin T1, CDK9 partner for transcription elongation), TADA2B (SAGA complex coactivator), ALYREF (mRNA nuclear export adaptor), CSNK1E (casein kinase regulating Wnt/circadian), and FBXO7 (F-box ubiquitin ligase). Together these point to a broadly active transcriptional co-regulation and mRNA processing program. PLXND1 and MXRA7 are outliers but weakly linked. The uniform expression and strong coherence suggest a housekeeping-level transcriptional machinery module rather than a stimulus-responsive program.
Genes
ALYREF, CCNT1, CSNK1E, FBXO7, MXRA7, PLEKHM2, PLXND1, TADA2B, WDR26, ZDHHC18
Most correlated modules
- mRNA Decay Program · correlation 0.89
- T cell Quiescence · correlation 0.85
- AP-1/MEF2 Activation · correlation 0.84
- NF-κB Activation · correlation 0.83
- NF-κB Negative Feedback · correlation 0.82
- Nuclear Receptor Chromatin · correlation 0.81
- Stress Granule Response · correlation 0.81
- Epigenetic Chromatin Regulation · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.