CCNT1 — Cyclin T1
CCNT1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CCNT1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Immediate early response BCR/AP1/NFKb pathway | CREM, HES4, JMY, JOSD1, KDM4B, NR4A3, PCNX4, PER1 +7 more | View in SCUBA |
| CD4⁺ T cells | TCR early activation TCR/AP1/NFKb pathway | ARIH1, BRAF, CLEC2D, ELL2, EMD, FAM133B, FOSL2, JOSD1 +11 more | View in SCUBA |
| Gamma-delta T cells | TCR Inhibitory Signaling Exhaustion | AFF4, CBLB, CCNH, CHD2, CRYBG1, FYN, ISG20, PARP8 +9 more | |
| Innate lymphoid cells | Prostaglandin-AP1 Response Inflammation | ARIH1, ARL5B, CHD1, CXCL2, ETV3, FOSL2, IRF2BP2, JOSD1 +12 more | View in SCUBA |
| Mucosal-associated invariant T cell | Transcriptional Co-regulation DNA/chromatin regulation | ALYREF, CSNK1E, FBXO7, MXRA7, PLEKHM2, PLXND1, TADA2B, WDR26 +1 more |
About the gene
| Synonyms | CCNT, CYCT1, HIVE1 |
|---|---|
| Chromosome | 12: 48688458-48716998 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Molecular function | Cyclin |
| Biological process | Cell cycle, Cell division, Host-virus interaction, Transcription, Transcription regulation |
Function
Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). Required to activate the protein kinase activity of CDK9: acts by mediating formation of liquid-liquid phase separation (LLPS) that enhances binding of P-TEFb to the CTD of RNA Pol II. (Microbial infection) In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.