ZNF808 — Zinc finger protein 808
ZNF808 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ZNF808's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Chromatin Remodeling DNA/chromatin regulation | ACTN4, ANP32E, AP2B1, CCDC82, EIF2B1, EXOSC10, FAR1, FLII +17 more | |
| Mucosal-associated invariant T cell | SWI/SNF Chromatin Remodeling DNA/chromatin regulation | ARCN1, ATL3, CASP8, CYFIP2, DENND4C, DIDO1, DPP4, ERAP1 +8 more |
About the gene
| Chromosome | 19: 52527652-52564464 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Transcription factors |
| Molecular function | DNA-binding |
| Biological process | Transcription |
Function
Transcriptional repressor that targets mainly transposable elements. Primarily targets the long terminal repeat of endogenous retroviruses classified as MER11 elements which comprise subfamilies A, B and C. May silence transposable elements through the establishment of heterochromatin-associated trimethylation of 'Lys-9' of histone H3 (H3K9me3). Can also bind to certain gene promoters and other genomic regions. Represses transcription of specific MER11 elements during differentiation toward pancreatic lineages in early pancreas development. By repressing transcription, prevents a liver gene expression program from being aberrantly activated during pancreas differentiation
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.