Chromatin Remodeling
Gene co-expression module in Gamma-delta T cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 26 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 15 of 26 genes have a known function matching the annotation |
Why this annotation
Hub genes include core NuRD complex members (MTA2, RBBP4), SWI/SNF subunit SMARCC2, cohesin RAD21, nuclear transport factor KPNB1, transcriptional coregulators HCFC1 and THRAP3, splicing factor SF3B3, RNA-binding NONO and TAF15, and DNA repair factor MRE11. The dominant theme is chromatin remodeling and transcriptional regulation centered on the NuRD and SWI/SNF complexes. Uniform expression across subsets and strong coherence indicate a housekeeping chromatin regulation program. Neighbor modules M91 and M42 also reflect nuclear housekeeping (nuclear envelope, splicing), consistent with co-regulated nuclear homeostasis programs.
Genes
ACTN4, ANP32E, AP2B1, CCDC82, EIF2B1, EXOSC10, FAR1, FLII, HCFC1, ILF3, IPO9, ITPR3, KPNB1, MRE11, MTA2, NONO, PSME3, RAD21, RBBP4, RNF4, SF3B3, SMARCC2, TAF15, TASOR, THRAP3, ZNF808
Most correlated modules
- Actin Cytoskeletal Regulation · correlation 0.89
- Vesicular Trafficking · correlation 0.88
- DNA Damage Response · correlation 0.87
- Metabolic-Translational Coupling · correlation 0.87
- Nuclear Pore Organization · correlation 0.86
- ER Antigen Processing · correlation 0.86
- Interferon Stimulated Genes · correlation 0.84
- Post-transcriptional RNA Regulation · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.