DENND4C — DENN domain containing 4C
DENND4C belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DENND4C's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Butyrophilin gd Activation TCR Signaling | ABI1, ADD3, ANXA6, ARHGAP1, ARHGAP25, ARHGAP30, ARHGEF2, BTN3A1 +16 more | |
| Macrophages | Endosomal Rab Trafficking Vesicular traficking | ABL1, ANKS1A, ARB2A, CAMK1D, CPEB3, DISC1, FBXL17, FTO +15 more | View in SCUBA |
| Mucosal-associated invariant T cell | SWI/SNF Chromatin Remodeling DNA/chromatin regulation | ARCN1, ATL3, CASP8, CYFIP2, DIDO1, DPP4, ERAP1, NFATC3 +8 more |
About the gene
| Synonyms | bA513M16.3, C9orf55, C9orf55B, FLJ20686, RAB10GEF |
|---|---|
| Chromosome | 9: 19230435-19374281 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Guanine-nucleotide releasing factor |
| Biological process | Protein transport, Transport |
Function
Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.