FLII — FLII actin remodeling protein
FLII belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FLII's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Chromatin Remodeling DNA/chromatin regulation | ACTN4, ANP32E, AP2B1, CCDC82, EIF2B1, EXOSC10, FAR1, HCFC1 +17 more | |
| Macrophages | Protein Biogenesis Housekeeping | ATP6V0D1, B3GAT3, BUD23, C11orf58, CHD4, CNPY2, DAZAP1, DDX46 +23 more | View in SCUBA |
| Mucosal-associated invariant T cell | Chromatin Remodeling DNA/chromatin regulation | ANP32E, ARHGAP30, CANX, DCTN1, EPRS1, HK1, JAK3, LASP1 +9 more |
About the gene
| Synonyms | FLI, Fli1, FLIL, MGC39265 |
|---|---|
| Chromosome | 17: 18244815-18258738 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Molecular function | Actin-binding, Activator |
| Biological process | Transcription, Transcription regulation |
Function
Is a regulator of actin polymerization, required for proper myofibril organization and regulation of the length of sarcomeric thin filaments (By similarity). It also plays a role in the assembly of cardiomyocyte cell adhesion complexes (By similarity). Regulates cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation (By similarity). May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.