CYFIP2 — Cytoplasmic FMR1 interacting protein 2
CYFIP2 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CYFIP2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | TCR Activation Signaling TCR Signaling | ADCY7, ATP2B4, DIAPH1, GK5, GLG1, ITGAL, NBEAL2, NFATC3 +4 more | |
| Hematopoietic progenitor cells | Lymphoid Progenitor TFs Lymphcyte development | ADAM28, AFF3, ANKRD44, CYLD, HLA-DMB, MEF2C, PDE7A, RNASEH2B +4 more | |
| Monocytes | Non-classical Monocyte Innate immunity | CD79B, CDH23, CDKN1C, CHST7, CKB, KNDC1, LYPD2, NEURL1 +6 more | View in SCUBA |
| Mucosal-associated invariant T cell | SWI/SNF Chromatin Remodeling DNA/chromatin regulation | ARCN1, ATL3, CASP8, DENND4C, DIDO1, DPP4, ERAP1, NFATC3 +8 more |
About the gene
| Synonyms | PIR121 |
|---|---|
| Chromosome | 5: 157266079-157395595 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Biological process | Apoptosis, Cell adhesion |
Function
Involved in T-cell adhesion and p53/TP53-dependent induction of apoptosis. Does not bind RNA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.