SWI/SNF Chromatin Remodeling
Gene co-expression module in Mucosal-associated invariant T cell
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 17 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 17 genes have a known function matching the annotation |
Why this annotation
SMARCC1 (SWI/SNF BAF complex core subunit, chromatin remodeling), ZNF91, ZNF808, ZKSCAN1 (KRAB zinc finger transcriptional repressors), DIDO1 (chromatin reader/apoptosis), TASOR-neighbor context, USP33 and VCPIP1 (deubiquitinases), NLRC3 (NLR immune regulator), CASP8 (apoptosis), ERAP1 (antigen processing), NFATC3 (NFAT TF), ATL3 (ER), ARCN1 (COPI vesicle). The dominant theme is chromatin remodeling and transcriptional repression via SWI/SNF (SMARCC1) and KRAB-ZNF repressors. NFATC3 connects to T cell transcriptional programs. The module resembles a chromatin regulatory program with immune gene silencing components. Neighbor to M40 (cytoskeletal/chromatin) and M67 (circadian repression), supporting a chromatin regulation neighborhood.
Genes
ARCN1, ATL3, CASP8, CYFIP2, DENND4C, DIDO1, DPP4, ERAP1, NFATC3, NLRC3, SMARCC1, TMPO, USP33, VCPIP1, ZKSCAN1, ZNF808, ZNF91
Most correlated modules
- Nuclear-Cytoskeletal Organization · correlation 0.86
- T cell Activation Signaling · correlation 0.85
- T cell Homeostasis · correlation 0.84
- Endosomal Actin Organization · correlation 0.83
- Nuclear regulatory housekeeping · correlation 0.80
- Circadian Transcriptional Regulation · correlation 0.79
- Chromatin Maintenance State · correlation 0.78
- Chromatin Complex Regulation · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.