Heat shock chaperones
Gene co-expression module in CD19⁺ B cells
| Category | Stress |
|---|---|
| Genes | 10 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 10 of 10 genes have a known function matching the annotation |
Why this annotation
This module is dominated by molecular chaperones: HSPD1/HSPE1 (mitochondrial chaperonin), HSP90AB1, HSPA8, HSPA9, TCP1 (CCT chaperonin), AHSA1 (HSP90 cochaperone), STIP1 (HOP), FKBP4 (HSP90 cochaperone), CACYBP. This is a coherent heat-shock/chaperone protein-folding program, a classic proteostatic stress response.
Genes
AHSA1, CACYBP, FKBP4, HSP90AB1, HSPA8, HSPA9, HSPD1, HSPE1, STIP1, TCP1
Most correlated modules
- mRNA splicing factors · correlation 0.73
- Heat Shock Response · correlation 0.60
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.