STIP1 — Stress induced phosphoprotein 1

STIP1 belongs to a gene co-expression module in 10 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

STIP1's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Heat shock chaperones Stress	AHSA1, CACYBP, FKBP4, HSP90AB1, HSPA8, HSPA9, HSPD1, HSPE1 +1 more	View in SCUBA
CD4⁺ T cells	Chaperone Proteostasis Protein processing & ER	BANF1, CCT3, CCT4, CCT5, FXR1, HNRNPH3, HSPB1, MAGOH +7 more	View in SCUBA
CD8⁺ T cells	RNA Processing Mixed RNA processing & translation	AIP, CALM1, EZR, FUBP1, HNRNPA2B1, HNRNPH3, LCP1, LRRFIP1 +8 more	View in SCUBA
Gamma-delta T cells	Heat Shock Response Stress	AHSA1, BAG3, CACYBP, CCT4, CHORDC1, DNAJA1, DNAJB1, DNAJB4 +13 more
Innate lymphoid cells	TRiC Chaperonin Folding Protein processing & ER	ATP6V0D1, CACYBP, CCT2, CCT3, CCT4, CCT5, EIF5A, ELOC +9 more	View in SCUBA
Lymphatic endothelial	Heat Shock Chaperone Stress	AHSA1, CCT4, CHORDC1, DNAJB6, FKBP4, HSPD1, TCP1	View in SCUBA
Macrophages	RAS-MAPK Signaling Housekeeping	ARF4, ATG12, CAMTA1, CDC37, CHMP4B, ETFA, GLA, HMGA1 +26 more	View in SCUBA
Monocytes	Co-chaperone Proteostasis Stress	AHSA1, ALAS1, BAG3, CACYBP, FBXL14, FKBP4, HSPA6, HSPB1 +2 more	View in SCUBA
Mucosal-associated invariant T cell	Heat Shock Response Stress	AHSA1, BAG3, CACYBP, CAPG, CHORDC1, CSF1, DNAJA4, DNAJB4 +13 more
Natural Killer cells	NK Inflammatory Activation Inflammation	BST2, CCT4, FCER1G, FGFR1OP2, ITM2B, LPIN2, LPXN, MBNL1 +1 more	View in SCUBA

About the gene

Synonyms	HOP, STI1
Chromosome	11: 64185272-64204543
Predicted location	Intracellular
Essential gene	No
Protein class	Plasma proteins, Predicted intracellular proteins

Function

Acts as a co-chaperone for HSP90AA1. Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (By similarity).

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.