mRNA splicing factors
Gene co-expression module in CD19⁺ B cells
| Category | RNA processing |
|---|---|
| Genes | 21 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 21 genes have a known function matching the annotation |
Why this annotation
Mixed module combining RNA-processing/splicing factors (SRSF2, SRSF3, HNRNPAB, EIF4A3, PTBP1, NXT1, HNRNPA2B1, TRIM28) with proliferation-associated genes (CKS2, UBE2S, ODC1, NASP, TUBB4B, TUBA4A) and metabolic/redox genes (CYCS, SOD1, PPIF, CALM1/2). The top hubs are splicing factors, suggesting the dominant program is RNA processing tied to a proliferative/biosynthetic state. Given the highest-PageRank genes are SRSF2, SRSF3, HNRNP and EIF4A3, RNA processing is the best single label.
Genes
CALM1, CALM2, CKS2, CYCS, EIF4A3, HNRNPA0, HNRNPA2B1, HNRNPAB, MRPS6, NASP, NXT1, ODC1, PPIF, PTBP1, SOD1, SRSF2, SRSF3, TRIM28, TUBA4A, TUBB4B, UBE2S
Most correlated modules
- Heat shock chaperones · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.