Heat Shock Response
Gene co-expression module in CD19⁺ B cells
| Category | Stress |
|---|---|
| Genes | 22 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 13 of 22 genes have a known function matching the annotation |
Why this annotation
Definitive heat shock response: HSPA1B, DNAJB4, HSPH1, HSPA1A, DNAJA4, DNAJB1, DNAJB6, HSPA6, HSP90AA1, BAG3, CHORDC1, ZFAND2A. Classic HSF1-driven chaperone/heat shock program, often a dissociation/proteotoxic stress signature. Core coherence and uniform expression. Neighbor of other stress modules.
Genes
BAG3, CHORDC1, DDIT4, DEDD2, DNAJA4, DNAJB1, DNAJB4, DNAJB6, EIF5, HSP90AA1, HSPA1A, HSPA1B, HSPA6, HSPB1, HSPH1, IER5, MRPL18, NABP1, RHOB, SLC5A3, TSPYL2, ZFAND2A
Most correlated modules
- Early Response Stress · correlation 0.79
- mRNA Splicing · correlation 0.72
- Integrated Stress Response · correlation 0.72
- AP-1 Immediate Early · correlation 0.71
- ATF4 Stress Response · correlation 0.71
- Immediate Early NFkB · correlation 0.69
- Immediate early response · correlation 0.67
- Heat shock chaperones · correlation 0.60
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.