FKBP4 — FKBP prolyl isomerase 4
FKBP4 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FKBP4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Heat shock chaperones Stress | AHSA1, CACYBP, HSP90AB1, HSPA8, HSPA9, HSPD1, HSPE1, STIP1 +1 more | View in SCUBA |
| CD4⁺ T cells | Heat-shock response Stress | AHSA1, BAG3, CACYBP, CCDC117, DNAJB6, DYNLL1, GADD45G, HSPA6 +5 more | View in SCUBA |
| Gamma-delta T cells | ER/Osmotic Stress Stress | ABHD3, DNAJA4, HIBCH, HSD17B7, HSPA4, HSPB1, MBNL2, MRPL18 +7 more | |
| Hematopoietic progenitor cells | Nucleotide Metabolism Housekeeping | DCTPP1, DNPH1, EIF4EBP1, GCSH, METTL26, MRPL12, NHP2, NME4 +2 more | |
| Lymphatic endothelial | Heat Shock Chaperone Stress | AHSA1, CCT4, CHORDC1, DNAJB6, HSPD1, STIP1, TCP1 | View in SCUBA |
| Monocytes | Co-chaperone Proteostasis Stress | AHSA1, ALAS1, BAG3, CACYBP, FBXL14, HSPA6, HSPB1, SERPINH1 +2 more | View in SCUBA |
| Natural Killer cells | Inducible HSP70 Stress Stress | BAG3, DNAJB1, HSPA1A, HSPA1B, HSPA4, HSPA6, HSPB1, RHOB +2 more | View in SCUBA |
About the gene
| Synonyms | FKBP52, FKBP59 |
|---|---|
| Chromosome | 12: 2794970-2805423 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Chaperone, Isomerase, Rotamase |
Function
Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Also acts as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.