SCUBA

CACYBP — Calcyclin binding protein

CACYBP belongs to a gene co-expression module in 10 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

CACYBP's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsHeat shock chaperones
Stress
AHSA1, FKBP4, HSP90AB1, HSPA8, HSPA9, HSPD1, HSPE1, STIP1 +1 moreView in SCUBA
CD4⁺ T cellsHeat-shock response
Stress
AHSA1, BAG3, CCDC117, DNAJB6, DYNLL1, FKBP4, GADD45G, HSPA6 +5 moreView in SCUBA
CD8⁺ T cellsHeat Shock Response
Stress
AHSA1, BAG3, CCT3, DNAJA1, HSP90AA1, HSP90AB1, HSPA8, HSPD1 +4 moreView in SCUBA
EndothelialStress RNA Processing
RNA processing & translation
ARF4, ELOC, ENY2, EWSR1, GNA14, HNRNPDL, HNRNPF, MAP3K13 +5 moreView in SCUBA
Gamma-delta T cellsHeat Shock Response
Stress
AHSA1, BAG3, CCT4, CHORDC1, DNAJA1, DNAJB1, DNAJB4, HSP90AA1 +13 more
Goblet cellsMitochondrial Chaperone
Protein processing & ER
ANP32B, C1QBP, DEK, HSPD1, HSPE1, LDHB, LSM2, PA2G4View in SCUBA
Innate lymphoid cellsTRiC Chaperonin Folding
Protein processing & ER
ATP6V0D1, CCT2, CCT3, CCT4, CCT5, EIF5A, ELOC, FAM162A +9 moreView in SCUBA
MonocytesCo-chaperone Proteostasis
Stress
AHSA1, ALAS1, BAG3, FBXL14, FKBP4, HSPA6, HSPB1, SERPINH1 +2 moreView in SCUBA
Mucosal-associated invariant T cellHeat Shock Response
Stress
AHSA1, BAG3, CAPG, CHORDC1, CSF1, DNAJA4, DNAJB4, GPR174 +13 more
Natural Killer cellsHeat Shock Response
Stress
AHSA1, ANKRD37, CHORDC1, HSP90AA1, HSP90AB1, HSPA8, HSPD1, HSPE1 +3 moreView in SCUBA

About the gene

SynonymsS100A6BP, SIP
Chromosome1: 174999163-175012027
Predicted locationIntracellular
Essential geneNo
Protein classPlasma proteins, Predicted intracellular proteins
Biological processUbl conjugation pathway

Function

May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1)

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.