AHSA1 — Activator of HSP90 ATPase activity 1

AHSA1 belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

AHSA1's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Heat shock chaperones Stress	CACYBP, FKBP4, HSP90AB1, HSPA8, HSPA9, HSPD1, HSPE1, STIP1 +1 more	View in SCUBA
CD4⁺ T cells	Heat-shock response Stress	BAG3, CACYBP, CCDC117, DNAJB6, DYNLL1, FKBP4, GADD45G, HSPA6 +5 more	View in SCUBA
CD8⁺ T cells	Heat Shock Response Stress	BAG3, CACYBP, CCT3, DNAJA1, HSP90AA1, HSP90AB1, HSPA8, HSPD1 +4 more	View in SCUBA
Gamma-delta T cells	Heat Shock Response Stress	BAG3, CACYBP, CCT4, CHORDC1, DNAJA1, DNAJB1, DNAJB4, HSP90AA1 +13 more
Innate lymphoid cells	Heat Shock Response Stress	ANKRD37, DEDD2, DNAJB1, DNAJB4, HSP90AA1, HSP90AB1, HSPA1A, HSPA1B +9 more	View in SCUBA
Lymphatic endothelial	Heat Shock Chaperone Stress	CCT4, CHORDC1, DNAJB6, FKBP4, HSPD1, STIP1, TCP1	View in SCUBA
Monocytes	Co-chaperone Proteostasis Stress	ALAS1, BAG3, CACYBP, FBXL14, FKBP4, HSPA6, HSPB1, SERPINH1 +2 more	View in SCUBA
Mucosal-associated invariant T cell	Heat Shock Response Stress	BAG3, CACYBP, CAPG, CHORDC1, CSF1, DNAJA4, DNAJB4, GPR174 +13 more
Natural Killer cells	Heat Shock Response Stress	ANKRD37, CACYBP, CHORDC1, HSP90AA1, HSP90AB1, HSPA8, HSPD1, HSPE1 +3 more	View in SCUBA

About the gene

Synonyms	Aha1, C14orf3, hAha1, p38
Chromosome	14: 77457870-77469472
Predicted location	Intracellular
Essential gene	No
Protein class	Plasma proteins, Predicted intracellular proteins, Transporters
Molecular function	Chaperone
Biological process	Host-virus interaction, Stress response

Function

Acts as a co-chaperone of HSP90AA1. Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity. Competes with the inhibitory co- chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins. Competes with the inhibitory co-chaperone TSC1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.