TCP1 — T-complex 1

TCP1 belongs to a gene co-expression module in 10 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

TCP1's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Heat shock chaperones Stress	AHSA1, CACYBP, FKBP4, HSP90AB1, HSPA8, HSPA9, HSPD1, HSPE1 +1 more	View in SCUBA
CD4⁺ T cells	Heat Shock Response Stress	ANKRD37, CHORDC1, DEDD2, DNAJA1, DNAJA4, DNAJB1, DNAJB4, HSP90AA1 +12 more	View in SCUBA
Gamma-delta T cells	Heat Shock Response Stress	AHSA1, BAG3, CACYBP, CCT4, CHORDC1, DNAJA1, DNAJB1, DNAJB4 +13 more
Goblet cells	CCT Chaperonin Complex Protein processing & ER	CCT5, CCT6A, HDGF, HNRNPA3, HNRNPC, IDH2, PTGES3, SMS +2 more	View in SCUBA
Innate lymphoid cells	Heat Shock Response Stress	AHSA1, ANKRD37, DEDD2, DNAJB1, DNAJB4, HSP90AA1, HSP90AB1, HSPA1A +9 more	View in SCUBA
Lymphatic endothelial	Heat Shock Chaperone Stress	AHSA1, CCT4, CHORDC1, DNAJB6, FKBP4, HSPD1, STIP1	View in SCUBA
Macrophages	RNA Splicing Processing Housekeeping	ARMCX3, CIRBP, ELK4, GATAD1, H3-3B, HNRNPA2B1, HNRNPA3, HNRNPL +13 more	View in SCUBA
Monocytes	Heat Shock Response Stress	CHORDC1, DNAJA1, DNAJB1, HSP90AA1, HSP90AB1, HSPA1A, HSPA1B, HSPA8 +4 more	View in SCUBA
Natural Killer cells	Heat Shock Response Stress	AHSA1, ANKRD37, CACYBP, CHORDC1, HSP90AA1, HSP90AB1, HSPA8, HSPD1 +3 more	View in SCUBA
Smooth muscle cells	Translation initiation/RNA-binding RNA processing & translation	BRI3, CDV3, EIF5, EPC1, FAM133B, FAM53C, FUS, MAFB +2 more	View in SCUBA

About the gene

Synonyms	CCT1, Ccta, D6S230E
Chromosome	6: 159778498-159789703
Predicted location	Intracellular
Essential gene	Yes
Protein class	Essential proteins, Plasma proteins, Predicted intracellular proteins
Molecular function	Chaperone, Hydrolase

Function

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.