Integrin Rap1 Signaling
Gene co-expression module in CD4⁺ T cells
| Category | migration & adhesion |
|---|---|
| Genes | 17 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 17 genes have a known function matching the annotation |
Why this annotation
Hub genes RAPGEF1 (C3G, Rap1 GEF), RALGDS, ATP2B4 (calcium ATPase), ITGA4 (integrin alpha4, gut-homing in T cells), GNA15 (G-protein signaling), NOTCH2 are signaling and adhesion/migration genes. ITGA4 is a key gut T cell homing integrin and RAPGEF1/RALGDS regulate integrin activation and Rap1 signaling. PLIN2 is a lipid droplet marker. The module is significantly upregulated with inflammation and reversed by treatment, consistent with an activation/migration-adhesion program. Neighbor of M153 sharing GEF/Rho-Rap signaling supports a migration/adhesion theme.
Genes
ARL3, ATP2B4, ATXN1, DR1, GDE1, GNA15, GRAMD1B, GTDC1, ITGA4, KIAA0319L, MOB1A, NCDN, NOTCH2, PLIN2, PPP1R16B, RALGDS, RAPGEF1
Most correlated modules
- Th17 effector · correlation 0.83
- TCR Complex Activation · correlation 0.83
- Actomyosin signaling · correlation 0.82
- Rho-GTPase Migration · correlation 0.81
- Proteasome translation · correlation 0.79
- ER protein processing · correlation 0.76
- T cell exhaustion · correlation 0.75
- Integrin adhesion · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.