RNA processing splicing
Gene co-expression module in CD4⁺ T cells
| Category | RNA processing |
|---|---|
| Genes | 20 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 13 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes are dominated by RNA processing and splicing/translation factors: ILF2 (NF-AT interacting, RNA-binding), PPM1G, RBM8A (EJC), BUD31/ZMAT2/SYF2 spliceosome, GTF3C6, DNAJC8, EIF2S1 translation initiation, RAN nucleocytoplasmic transport, PSMD8 proteasome. The module reflects a broad RNA processing/biosynthetic program, uniformly expressed. Like M12 it is a metabolic/biosynthetic housekeeping cluster, but with a clear RNA processing emphasis.
Genes
BUD31, DNAJC8, EDF1, EIF2S1, GTF3C6, HPRT1, ILF2, LAMTOR5, MIIP, NDUFA2, OAZ1, PARK7, PDAP1, PMF1, PPM1G, PSMD8, RAN, RBM8A, SRA1, ZMAT2
Most correlated modules
- Proteasome/translation · correlation 0.95
- Proteostasis OxPhos · correlation 0.93
- NF-kB regulation · correlation 0.88
- T-cell activation · correlation 0.88
- Cellular biosynthesis · correlation 0.84
- Mitochondrial OxPhos · correlation 0.84
- Proteasome translation · correlation 0.83
- ER protein processing · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.