Cell motility/adhesion
Gene co-expression module in CD4⁺ T cells
| Category | migration & adhesion |
|---|---|
| Genes | 23 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 23 genes have a known function matching the annotation |
Why this annotation
Hub genes S100A6, S100A4, ANXA2, LGALS1, LGALS3, TMSB4X, MYL12A, LCP1 form a classic motility/cytoskeletal-adhesion signature with calcium-binding S100 proteins, galectins, and actin-regulatory proteins. TIMP1, TIMP1, ANXA2 link to matrix remodeling and migration. This resembles an activated/effector-memory T cell migratory program rather than a contamination signal (uniform expression, strong coherence). The dominant theme is cell motility/adhesion driven by S100/galectin/cytoskeleton proteins.
Genes
ANXA2, CCDC107, CYBA, FAM50A, GLIPR2, GRAP2, GYG1, ITM2B, LCP1, LGALS1, LGALS3, M6PR, MYL12A, ORAI1, PDIA3, RABAC1, S100A4, S100A6, TAPBP, TIMP1, TMSB4X, TNFSF12, TRADD
Most correlated modules
- Actin Cytoskeleton · correlation 0.85
- Th17 lineage · correlation 0.75
- T cell co-receptors · correlation 0.72
- Gamma-delta T cell · correlation 0.70
- Inflammatory activation · correlation 0.62
- Cytokine receptor signaling · correlation 0.60
- Effector activation NFkB · correlation 0.58
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.