Nucleotide biosynthesis
Gene co-expression module in CD4⁺ T cells
| Category | Housekeeping |
|---|---|
| Genes | 15 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 15 genes have a known function matching the annotation |
Why this annotation
Module dominated by nucleolar/rRNA processing (NHP2), polyamine and nucleotide biosynthesis (SRM, NME1, DCTPP1, PPA1), spliceosome (SNRPE), mitochondrial ribosome (MRPL12, MRPL4), chaperonin (CCT7), and methyltransferase PRMT1. This is a proliferation-associated biosynthetic/anabolic program, upregulated with inflammation. Reflects activated/proliferating T cell metabolic state.
Genes
CCT7, COPRS, DCTPP1, MRPL12, MRPL4, NHP2, NME1, PPA1, PRDX4, PRMT1, SNRPE, SRM, SRPRB, TIMM13, ZNF593
Most correlated modules
- ER protein processing · correlation 0.84
- TNF activation survival · correlation 0.83
- Ribosome biogenesis · correlation 0.75
- Proteasome/translation · correlation 0.72
- NF-kB activation · correlation 0.71
- ER stress UPR · correlation 0.62
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.