Integrated Stress Response
Gene co-expression module in CD4⁺ T cells
| Category | Stress |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 9 genes have a known function matching the annotation |
Why this annotation
DDIT3 (CHOP), IFRD1, EIF1, EIF4A3, GTF2B, CYCS, PTMA, NASP, TUBA1A. DDIT3 is the master integrated-stress-response transcription factor; combined with translation initiation factors (EIF1, EIF4A3) and IFRD1. This is an integrated stress response / translational stress module, neighbor to UPR modules M76 and M131.
Genes
CYCS, DDIT3, EIF1, EIF4A3, GTF2B, IFRD1, NASP, PTMA, TUBA1A
Most correlated modules
- Pol II Transcription Regulation · correlation 0.85
- Unfolded Protein Response · correlation 0.84
- T cell quiescence · correlation 0.74
- Immediate Early AP-1 · correlation 0.73
- Hypoxia metabolic stress · correlation 0.71
- Glucocorticoid Immunoregulation · correlation 0.65
- NF-kB Feedback Response · correlation 0.62
- Immediate early activation · correlation 0.61
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.