Naive T cell
Gene co-expression module in CD4⁺ T cells
| Category | T cell development |
|---|---|
| Genes | 30 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 30 genes have a known function matching the annotation |
Why this annotation
LEF1 and SELL are canonical naive/central memory T cell transcription factor and homing markers; FHIT, AK5, TRABD2A, BEX2, ENC1 are associated with naive/resting T cell states. TRABD2A (TIKI2) is a Wnt regulator linked to quiescent T cells. This module is a naive/quiescent T cell program, neighbor to M95 (also naive egress), reinforcing the shared identity. AIF1 and KRT72 are peripheral/possible noise but module coherence is high.
Genes
AIF1, AK5, APBA2, BEND5, BEX2, C1orf162, CBR3, CYSLTR1, ENC1, FAM117B, FHIT, HOOK1, HRH2, IGF1R, KRT72, LDLRAP1, LEF1, LYPD3, NELL2, NET1, NOG, RBM11, SCML1, SELL, SH3YL1, SULT1B1, TCEA3, TRABD2A, USP44, ZBED3
Most correlated modules
- Naive T quiescence · correlation 0.89
- Naive resting T cell · correlation 0.77
- Hypoxia metabolic stress · correlation 0.76
- Naive T cell · correlation 0.72
- Immediate early activation · correlation 0.70
- T cell signaling · correlation 0.54
- TCR signaling · correlation 0.45
- Translation machinery · correlation 0.38
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.