Tfh program
Gene co-expression module in CD4⁺ T cells
| Category | B cell help |
|---|---|
| Genes | 19 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 19 genes have a known function matching the annotation |
Why this annotation
Strong follicular helper T cell signature: CXCR5 (core, defining Tfh marker), TOX and TOX2 (Tfh transcription factors), SMAD1, IL6R, ST8SIA1, PASK. This is a canonical Tfh/B cell help program, consistent with the Tfh-enriched neighborhood (M137 with IL21/CXCL13).
Genes
BAZ2B, CCDC50, CDK5R1, CXCR5, IL6R, LY96, MTUS1, PASK, PIP4P2, PVALB, SCGB3A1, SH3TC1, SMAD1, SMPD3, ST8SIA1, STK39, THADA, TOX, TOX2
Most correlated modules
- NFAT activation · correlation 0.79
- CD200 immunoregulation · correlation 0.79
- Tfh CXCL13 program · correlation 0.72
- TCR signaling activation · correlation 0.60
- Tfh IL21 help · correlation 0.59
- Naive resting T cell · correlation 0.54
- Post-transcriptional regulation · correlation 0.47
- Leukocyte adhesion signaling · correlation 0.47
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.