OxPhos & proteasome
Gene co-expression module in CD4⁺ T cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 19 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 19 genes have a known function matching the annotation |
Why this annotation
Top hubs are proteasome (PSMD4, PSMB4), mitochondrial ribosomal (MRPL51, MRPL41), and OxPhos genes (COX5A, NDUFA4, NDUFB7, COX17). This is a mixed housekeeping/metabolic module with strong OxPhos/mitochondrial component plus proteostasis. Uniform low expression. The OxPhos and mito-ribosome signature dominates the gene list, and the module is inflammation-associated (likely metabolic activation of T cells).
Genes
CCDC167, CLTA, COX17, COX5A, DBI, FKBP1A, FMNL1, GALM, MRPL41, MRPL51, NDUFA4, NDUFB7, PSMB4, PSMD4, RTRAF, SNRPC, SUMO1, VCP, ZCRB1
Most correlated modules
- Oxidative Phosphorylation · correlation 0.93
- Interferon response · correlation 0.90
- Lipid Metabolism · correlation 0.89
- Cytoskeleton & metabolism · correlation 0.89
- Mitochondrial Translation · correlation 0.88
- OxPhos & redox · correlation 0.88
- Immune Regulation · correlation 0.87
- Actin cytoskeleton · correlation 0.86
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.