Th17 effector
Gene co-expression module in CD4⁺ T cells
| Category | Th17 fate |
|---|---|
| Genes | 15 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 5 of 15 genes have a known function matching the annotation |
Why this annotation
Hub genes include IL17A (signature Th17 cytokine), CD6 (T cell costimulatory), SPN (CD43), and NFIL3 (regulator of IL17 and Th17/ILC programs). TBXAS1 and PLPP1 are lipid mediator enzymes. The presence of IL17A with positive correlation to inflammation in both UC and CD strongly supports a Th17 effector program in inflamed intestine.
Genes
CD6, CLSTN3, CTDSP1, IL17A, ITPRIPL2, MAP3K4, MPRIP, NFIL3, NMRK1, PLPP1, PTPN18, SPN, TBC1D2B, TBXAS1, TMPRSS3
Most correlated modules
- Inflammatory activation · correlation 0.84
- TCR Complex Activation · correlation 0.84
- Integrin Rap1 Signaling · correlation 0.83
- Th17 lineage · correlation 0.83
- Rho-GTPase Migration · correlation 0.82
- Cytotoxic effector · correlation 0.79
- Gamma-delta T cell · correlation 0.78
- Integrin Adhesion Migration · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.