TCR Activation Signaling
Gene co-expression module in CD4⁺ T cells
| Category | TCR/AP1/NFKb pathway |
|---|---|
| Genes | 15 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 15 genes have a known function matching the annotation |
Why this annotation
Hub genes LAX1, PTPN22, WIPF1, NEDD9, RASGRP1-like signaling, AKNA and BCL2L11 are all linked to T-cell receptor signaling and activation. PTPN22 is a key TCR signaling phosphatase, LAX1 is a TCR-proximal adaptor, WIPF1/NEDD9 are involved in immune synapse cytoskeleton, BCL2L11 (BIM) mediates activation-induced apoptosis. The inflammation-up/treatment-down pattern fits an activated T-cell state. NAA50 and some RNA-processing genes are peripheral.
Genes
AKNA, ATP6V1A, BCL2L11, KIF20B, LAX1, NAA50, NEDD9, NPC1, PRKAR1A, PTPN22, RAP2A, SLBP, WAC, WIPF1, WTAP
Most correlated modules
- Interferon Response · correlation 0.86
- JAK-STAT Signaling · correlation 0.81
- Cytoskeleton & metabolism · correlation 0.81
- Immune Regulation · correlation 0.78
- Chemokine Migration · correlation 0.78
- RNA & Chromatin Regulation · correlation 0.77
- Interferon response · correlation 0.76
- Actomyosin signaling · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.