Leukocyte adhesion signaling
Gene co-expression module in CD4⁺ T cells
| Category | migration & adhesion |
|---|---|
| Genes | 31 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 31 genes have a known function matching the annotation |
Why this annotation
Mixed module: leukocyte adhesion/integrin signaling (ICAM3, ITGB2, LIMD2), diacylglycerol kinases (DGKA, DGKZ) regulating TCR signaling, translation initiation (EIF3F, EIF3L, EIF4B), and OxPhos (UQCRB). The adhesion/TCR-modulating genes (ICAM3, ITGB2, DGKA, DGKZ, BIN1) give a leukocyte signaling/adhesion identity associated with inflammation.
Genes
ARHGDIB, BIN1, CD37, DGKA, DGKZ, EIF3F, EIF3L, EIF4B, GYPC, ICAM3, IGBP1, ITGB2, LIMD2, MAD1L1, MFNG, MZT2A, NBDY, OCIAD2, OXA1L, PGLS, PIK3IP1, PSIP1, SNRPD2, SNRPN, SSR2, TEX264, TNFRSF10A, TSTD1, UQCRB, USP22, VPS51
Most correlated modules
- Translation machinery · correlation 0.68
- TCR signaling activation · correlation 0.67
- Ribosome biogenesis · correlation 0.56
- Post-transcriptional regulation · correlation 0.53
- Tfh program · correlation 0.47
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.